Utilization of Hydrogen Carrier Gas on a High-Resolution GC-TOFMS System: An Application Compendium

This application compendium explores the integration of hydrogen as a carrier gas in high-resolution gas chromatography-time-of-flight mass spectrometry (GC-TOFMS) systems, specifically the Pegasus® GC-HRT. Addressing the challenges posed by the diminishing helium supply and the increasing demand for rapid sample throughput, the document presents methodologies and data from diverse application markets, including specialty chemicals, forensic analysis, and metabolomics. The compendium demonstrates how hydrogen carrier gas can be effectively utilized to enhance analytical performance across these varied fields.