LECO Solutions for 代谢组学

代谢组学提出了从样本引入到所用分析方法的挑战，以及解释结果所需的数据减少。没有单一的分析技术可用于代谢组的完整表征，也没有完全表征代谢组。 尽管面临这些挑战，但 LECO 的即时衍生器与气相色谱质谱仪 （GC-MS） 相结合，提供了一种将样品引入 GC-MS 并分析主要代谢组的既定方法，而其他技术则只是研究次要和三级代谢物。代谢组学的主要挑战之一是检测和识别未知物质；您需要知道样本中还有哪些其他物质才能成功表征它，我们的 GC-MS 解决方案为您提供了明显的优势。我们的解决方案具有强大的自动衍生化和样品入门方法、分离、准确度、解析能力、解卷积和速度，以表征最复杂的代谢物谱。

Application Notes

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• A Comprehensive GC-TOFMS Metabolomics Workflow

  Early Type 2 Diabetes prediction can be facilitated by the implementation of a metabolomics method for the identification of T2DM biomarkers. A complete automated derivatization workflow is explored.

• Application of GC High Resolution Time-of-Flight Mass Spectrometry to Mouse Liver Metabolomic Analyses

  Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls associated with non-alcoholic fatty liver disease.

• Enhanced Metabolite Profiling: Hard and Soft Ionization High-Resolution Time-of-Flight Mass Spectrometry

• High-Resolution GCxGC for Improved Yeast Metabolite Characterization

• How Comprehensive is Your Analysis? Human Molecular Profiling Using High Resolution Time-of-Flight Mass Spectrometry

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